1. Nanomaterials for low-molecular-weight MALDI-TOF MS

○ MALDI-TOF MS: matrix-assisted laser desorption/ionization – time of flight mass spectrometry

○ Nanostructured solid matrix chips including parylene-matrix chip and TiO₂ nanowire chip for:
　- Elimination of organic matrix noise (< 500 Da range)
　- Enhancement of ionization/desorption efficiency without organic matrices
　- Quantitative analysis of low-molecular-weight biomolecules

2. Medical diagnosis based on low-molecular-weight MALDI-TOF MS

○ Multiple biomarker screening and quantitative/simultaneous analysis in human sera

○ Medical diagnosis and mortality prediction based on biomarker analysis using low-molecular-weight MALDI-TOF MS

3. Rapid detection of multidrug-resistant bacteria

○ Monitoring of small antibiotic molecule modification by modifying enzymes in antibiotic-resistant bacteria
　 (e.g. beta-lactamase, aminoglycoside-phosphotransferase, …)

○ Machine learning algorithm for classification of antibiotic-resistant and -susceptible bacteria using their mass spectrum

○ Bacteriophage-coated plate for specific capture and detection of antibiotic-resistant bacteria